Promoter targeted bisulfite sequencing reveals DNA methylation profiles associated with low sperm motility in asthenozoospermia
نویسندگان
چکیده
منابع مشابه
Targeted Bisulfite Sequencing-Based Analysis of MGMT Promoter Methylation in Meningiomas.
Currently we are working on the role of aberrant DNA methylation in pathogenesis and progression of meningiomas brain tumors frequently diagnosed in adults. For this reason we read an article by Larijani et al. published in APJCP Vol 15, 2014 with a special interest. This article concerns the role of promoter methylation of MGMT gene promoter in benign and malignant meningomas. The authors repo...
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Background and purpose: Hyperlipidemia is one of the main risk factors for coronary artery disease and is defined as abnormal elevation of lipids or lipoproteins in the blood. Pcsk9 is the ninth member of the proprotein convertase family that binds to the LDLR on the surface of the hepatocyte, leading to degradation of LDLR in lysosomes which could cause hyperlipidemia. The present study aimed...
متن کاملGenome-wide DNA methylation profiles changes associated with constant heat stress in pigs as measured by bisulfite sequencing
Heat stress affects muscle development and meat quality in food animals; however, little is known regarding its regulatory mechanisms at the epigenetic level, such as via DNA methylation. In this study, we aimed to compare the DNA methylation profiles between control and heat-stressed pigs to identify candidate genes for skeletal muscle development and meat quality. Whole-genome bisulfite seque...
متن کاملBisulfite Sequencing Reveals That Aspergillus flavus Holds a Hollow in DNA Methylation
Aspergillus flavus first gained scientific attention for its production of aflatoxin. The underlying regulation of aflatoxin biosynthesis has been serving as a theoretical model for biosynthesis of other microbial secondary metabolites. Nevertheless, for several decades, the DNA methylation status, one of the important epigenomic modifications involved in gene regulation, in A. flavus remains t...
متن کاملIntegrative DNA Methylation and Gene Expression Analyses Identify DNA Packaging and Epigenetic Regulatory Genes Associated with Low Motility Sperm
BACKGROUND In previous studies using candidate gene approaches, low sperm count (oligospermia) has been associated with altered sperm mRNA content and DNA methylation in both imprinted and non-imprinted genes. We performed a genome-wide analysis of sperm DNA methylation and mRNA content to test for associations with sperm function. METHODS AND RESULTS Sperm DNA and mRNA were isolated from 21 ...
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ژورنال
عنوان ژورنال: Human Reproduction
سال: 2015
ISSN: 0268-1161,1460-2350
DOI: 10.1093/humrep/dev283